V(D)J recombination
THE PROCESS IN WHICH IMMUNE RECEPTOR V, D, AND J, OR V AND J GENE SEGMENTS, DEPENDING ON THE SPECIFIC RECEPTOR, ARE RECOMBINED WITHIN A SINGLE LOCUS UTILIZING THE CONSERVED HEPTAMER AND NONOMER RECOMBINATION SIGNAL SEQUENCES (RSS).
VDJ recombination; Antibody gene rearrangement; VDJ recombinase; V(D)J recombinase; Antibody gene recombination; Gene arrangement; Gene re-arrangement; V-J joining; VJ recombinase; Combinatorial diversification; 12/23 rule; Somatic recombination model; Gene rearrangement; Immunogobulin gene; J gene segment; D gene segment; D segment; J segment; J region; Joining gene segment; Diversity gene segment; Vdj recombinase
V(D)J recombination is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. It results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors (TCRs) found in B cells and T cells, respectively.